FIGURE

Fig. 1

ID

ZDB-FIG-181130-24

Publication

Castillo-Robles et al., 2018 - smarce1 mutants have a defective endocardium and an increased expression of cardiac transcription factors in zebrafish

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Fig. 1

(A) Schematic diagram of smarce1 gene. The DNA-binding high mobility group is shown. CRISPR/Cas9 mediated-deletions were produced in exon IV. The nucleotide sequence of the RNA-guide targeted region is shown in gray with the PAM in red and the deletions are indicated in lines below. (B) The body curvature, smaller eyes and cardiac edema are shown. (C) Graphs showing rescue experiments with injected smarce1 mRNA. A significant lower number of edematous embryos (left) and a higher survival rate (right) were determined in groups of the mRNA-injected relative to buffer-injected embryos. Values represent the average of three independent injections of 100 ± 10 embryos per experiment. ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	smarce1^una1/una1 smarce1^una2/una2 smarce1^una1/+; smarce1^una2/+
Observed In:	eye heart post-vent region
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.