FIGURE

Fig. S4

ID

ZDB-FIG-181127-32

Publication

Mochizuki et al., 2018 - Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish

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Fig. S4

Lens phenotypes of the zebrafish vps45 non-sense mutant allele

(A) Heads of wild-type and vps45sa14216 mutants. As in rw341 mutants, a small lens fiber core is observed in the eye cup of vps45sa14216 mutants.

(B) Sections of wild-type and vps45sa14216 mutant eyes. Like rw341 mutants, lens epithelium is disrupted to form multiple layers in vps45sa14216 mutants (arrowheads). Suture formation of elongating lens fibers is also abnormal in vps45sa14216 mutants (asterisk).

(C) Pax6 expression (green) in wild-type and vps45sa14216 mutant lenses. In wild type, Pax6 is expressed in a monolayer of lens epithelial cells (arrowheads). In vps45sa14216 mutants, Pax6 expression was detected, but becomes weaker than in wild type lenses (arrowheads).

(D) Prox1 expression (green) in wild-type and vps45sa14216 mutant lenses. In wild type lenses, Prox1 is expressed only in early differentiating lens fiber cells (arrows). In vps45sa14216 mutants, Prox1 is ectopically expressed in multilayered anterior lens epithelium (arrowheads). Scale bars: 20 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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