FIGURE

Fig. S5

ID

ZDB-FIG-180907-15

Publication

Powell et al., 2017 - Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues

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Fig. S5

Cxcr2 mutant variant recapitulates neutrophil resolution and migration phenotype, related to Figure 1

(A) Sudan black staining of neutrophils at the wound in a variant Cxcr2-/-. (B) Quantification of neutrophils at wound reveals an increase in neutrophils at 3 and 6 hpw in Cxcr2-/- (n= 3hpw 71, 69; 6hpw 84, 59). (C) Neutrophil duration at wound is increased in Cxcr2-/- variant 9 (n= 20, each). (D) Neutrophil (green) recruitment to otic vesicle injection of zCxcl8 supernatant is decreased in Cxcr2-/- var9 compared to WT. (E) Number of neutrophils in the otic vesicle of Cxcl8a or control supernatant injected larvae (n= ctrl 42, 33; Cxcl8 36, 29). (F) Neutrophil fold change response to Cxcl8a over control supernatant. *p<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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