Fig. 4
- ID
- ZDB-FIG-180827-16
- Publication
- Ferrero et al., 2018 - Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish
- Other Figures
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Kinetics of Adult MG Emergence during Zebrafish Development (A) Scheme of the transgenic lines used to discriminate pMF-derived embryonic MG from endothelial-derived adult MG. (B) GFP (left panels) and DsRed (middle panels) immunostaining performed on brain sections from Tg(kdrl:Cre; ßactin:Switch-DsRed; mpeg1:GFP) triple transgenics at the indicated developmental stage, showing the replacement of GFP+ DsRed− embryonic MG by GFP+ DsRed+ cells in the brain parenchyma. The right panels show a merge of both fluorescent channels. Scale bar: 50 μm. (C) Quantification of DsRed+ MG in the brain parenchyma during zebrafish development, determined as percent recombination among the whole GFP+ MG population. Error bars represent mean ± SEM of pooled data from two experiments (n = 3). MG, microglia. |
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Stage Range: | Days 7-13 to Days 45-89 |