FIGURE

Fig. 3

ID

ZDB-FIG-180824-2

Publication

Corral-Serrano et al., 2018 - C2orf71a/pcare1 is important for photoreceptor outer segment morphogenesis and visual function in zebrafish

Other Figures

Fig. 3

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Fig. 3

Pcare1^{rmc100/rmc100} zebrafish show aberrant photoreceptor morphology. (A) Analysis of the morphology of the pcare1^{rmc100/rmc100} zebrafish larval retina (5 dpf) using boron-dipyrromethene (BODIPY) revealed disorganization of photoreceptor outer segments as compared to those of strain- and age-matched wild-type larvae (arrows). (B) Siblings of adult zebrafish without (wild-type) or containing (pcare1^{rmc100/rmc100}) the 29 bp deletion in pcare1 were sectioned and stained with antibodies against F-actin (red), Rhodopsin (green) or, in (C) GNAT2 (green). Arrows indicate normal outer segments in control fish and dysmorphic outer segments in mutant fish. Nuclei were stained with DAPI.

Expression Data

Antibodies:	Ab2-gnat2 Ab5-rho
Fish:	WT pcare1^{rmc100/rmc100}
Anatomical Terms:	retinal cone cell retinal rod cell
Stage Range:	Day 5 to Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pcare1^{rmc100/rmc100}
Observed In:	optomotor response photoreceptor inner segment layer photoreceptor outer segment layer visual behavior
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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