FIGURE

Fig. 5

ID
ZDB-FIG-180808-9
Publication
Yu et al., 2018 - Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function
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Fig. 5

Proliferating germ cells were reduced, but apoptotic germ cells increased in ar-null zebrafish testes. (A, B) Immunofluorescent staining with anti-vasa antibody identified different types of spermatogenic cells in ar -/- testes and wildtype sibling (ar +/+) testes at 70 dpf or 4.5 mpf, respectively. SG, spermatogonia; SZ, spermatozoa; PSP, primary spermatocyte; SSP, secondary spermatocyte; SPD, spermatid. (C) Immunohistochemistry with anti-cyclin D1 antibody indicated that proliferating germ cells were reduced in ar -/- testes compared with wildtype (ar+/+) siblings at 4.5 mpf. (D) TUNEL assay indicated increased apoptosis of germ cells in ar -/- testes compared with wildtype (ar +/+) siblings at 4.5 mpf. Mpf, months post fertilization. (E, F) Expression of ccnd2a (cyclin d2a) was down-regulated, but expression of gsdf was up-regulated in ar-/- (ar ihb1225/ihb1225) testes compared with wildtype (ar +/+) sibling testes (4.5 mpf, n=3, respectively).
Expression Data
Genes:
Fish:
Anatomical Terms:
Stage Range: Days 45-89 to Adult

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In: (all 6)
Stage Range: Days 45-89 to Adult

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oncotarget
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