Fig. 1
- ID
- ZDB-FIG-180712-77
- Publication
- Esancy et al., 2018 - A zebrafish and mouse model for selective pruritus via direct activation of TRPA1
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Imiquimod produces behavioral and neuronal responses in the zebrafish. (A?H) 3dpf live elavl3:CaMPARI TG imaging of larvae exposed to 405 nm light and control (A), 50 ?M allyl isothiocyanate (AITC) (B), 100 ?M imiquimod (IMQ) (C), 100 ?M histamine (HIST) (D), 500 ?M serotonin (5-HT) (E), 100 ?M SLIGRL-NH2 (F), 100 ?M deoxycholic acid (DCA) (G), and 100 ?M loxoribine (LOX) solutions (H). (I), Counts of photoconverted cells from experiments (A-H). (J), 5dpf WT larval locomotor behavior screen. (K) Representative traces of adult behavior. (L) Adult lip-rubbing behavioral assay. (I, J, L) ***p<0.001, **p<0.01, one-way ANOVA. Bars represent mean ± s.e.m. |
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| Stage: | Protruding-mouth |
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| Stage Range: | Protruding-mouth to Adult |