FIGURE

Fig. S1

ID

ZDB-FIG-180711-35

Publication

Selland et al., 2018 - Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development

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Fig. S1

Morphology of paralog group 1 hox mutants.

Embryos were imaged consecutively at 22hpf (A–D), 48hpf (E-H) and 72hpf (I–L) to examine gross morphological defects. Hoxb1a^−/− mutants (B, F, J) do not have any major morphological defects as compared to wildtype embryos. (A, E, I) Hoxb1b^−/− mutants have a small otic vesicle at 22hpf (C) which does not persist at later stages (G, K). Hoxb1a^−/− hoxb1b^−/− mutants have a small otic vesicle at 22hpf (D) and develop cardiac edema at later stages (H, L). All embryos have been genotyped for hoxb1a^sa1191 and hoxb1b^ua1006. All embryos are lateral views, anterior to the left. Hpf, hours post fertilization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hoxb1b^{ua1006/ua1006} hoxb1a^{sa1191/sa1191}; hoxb1b^{ua1006/ua1006}
Observed In:	otic vesicle pericardium
Stage Range:	26+ somites to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 150, Selland, L.G., Koch, S., Laraque, M., Waskiewicz, A.J., Coordinate regulation of retinoic acid synthesis by pbx genes and fibroblast growth factor signaling by hoxb1b is required for hindbrain patterning and development, 28-41, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.