FIGURE

Fig. 6

ID

ZDB-FIG-180502-36

Publication

Owlarn et al., 2017 - Generic wound signals initiate regeneration in missing-tissue contexts

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Fig. 6

The wound epidermis of dormant fins is not a barrier to regeneration. a Transient inhibition of Wnt/β-catenin signaling using overexpression of Axin1 in hsp70l:Axin1-YFP transgenic fish resulted in a stable blockage of fin ray regeneration. n = 9 fish. b Amputation and heat-shock regime used to produce recessed rays in dormant fins. Note that interray skin healed distally to non-regenerating recessed rays (asterisk) despite Axin1-YFP expression. c Skin wounding applied to the skin distal to recessed dormant rays (black arrowheads) induced regenerative growth beyond the primary amputation plane. Asterisks indicate non-injured control rays. Graph depicts the fraction of regenerating rays. ***p < 0.001 χ ² test. n (non-injured) = 48 rays, 48 fish, two experiments, n (wounded) = 69 rays, 50 fish, two experiments. Scale bars: 500 µm

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.