PUBLICATION
Generic wound signals initiate regeneration in missing-tissue contexts
- Authors
- Owlarn, S., Klenner, F., Schmidt, D., Rabert, F., Tomasso, A., Reuter, H., Mulaw, M.A., Moritz, S., Gentile, L., Weidinger, G., Bartscherer, K.
- ID
- ZDB-PUB-171224-1
- Date
- 2017
- Source
- Nature communications 8: 2282 (Journal)
- Registered Authors
- Klenner, Felix, Weidinger, Gilbert
- Keywords
- none
- MeSH Terms
-
- Animal Fins/physiology
- Animals
- Head/physiology
- MAP Kinase Signaling System/genetics*
- Planarians/genetics*
- Planarians/physiology
- Regeneration/genetics*
- Regeneration/physiology
- Signal Transduction
- Wnt Signaling Pathway/genetics*
- Wound Healing/genetics*
- Wound Healing/physiology
- Wounds and Injuries
- Zebrafish/genetics*
- Zebrafish/physiology
- PubMed
- 29273738 Full text @ Nat. Commun.
Citation
Owlarn, S., Klenner, F., Schmidt, D., Rabert, F., Tomasso, A., Reuter, H., Mulaw, M.A., Moritz, S., Gentile, L., Weidinger, G., Bartscherer, K. (2017) Generic wound signals initiate regeneration in missing-tissue contexts. Nature communications. 8:2282.
Abstract
Despite the identification of numerous regulators of regeneration in different animal models, a fundamental question remains: why do some wounds trigger the full regeneration of lost body parts, whereas others resolve by mere healing? By selectively inhibiting regeneration initiation, but not the formation of a wound epidermis, here we create headless planarians and finless zebrafish. Strikingly, in both missing-tissue contexts, injuries that normally do not trigger regeneration activate complete restoration of heads and fin rays. Our results demonstrate that generic wound signals have regeneration-inducing power. However, they are interpreted as regeneration triggers only in a permissive tissue context: when body parts are missing, or when tissue-resident polarity signals, such as Wnt activity in planarians, are modified. Hence, the ability to decode generic wound-induced signals as regeneration-initiating cues may be the crucial difference that distinguishes animals that regenerate from those that cannot.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping