FIGURE

Fig. 8

ID

ZDB-FIG-180413-29

Publication

Dunn et al., 2017 - Dual Roles of Fer Kinase Are Required for Proper Hematopoiesis and Vascular Endothelium Organization during Zebrafish Development

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Fig. 8

Fer functions independently of Notch for erythrocyte population expansion but not intersomitic vessel formation. Co-injection of the Notch Intracellular Domain (NICD), along with wildtype (WT) or kinase-inactive (KD) Fer, showed that active Notch partially rescues vascular migration in the absence of Fer (fli1: (F)—WT, (I)—KD), but not excess erythrocyte proliferation (gata1: (D), WT, (G), KD; scl: (E), WT, (H), KD), when compared to fer-MO1 embryos containing only the NICD (J,K,L). Control MO embryos with injected NICD show normal gene expression of gata1 (A), scl (B) and fli1 (C). fer-MO1 alone—gata1 (M), scl (N) and fli1 (O). Embryos examined at 30 somites (~28 hpf).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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