FIGURE

Fig. 4

ID

ZDB-FIG-180404-44

Publication

Liu et al., 2017 - Overexpression of DYRK1A, a Down Syndrome Candidate gene, Impairs Primordial Germ Cells Maintenance and Migration in zebrafish

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Fig. 4

Overexpression of DYRK1A induces vasa-marked PGCs deficiency in early zebrafish embryo. Analysis of localization and strength of vasa positive cells in DYRK1A overexpressed embryos by WISH at 50% Epiboly stage (a), 8-somite stage (b) and Prim-5 stage (c). Histogram representing the relative expression detected by qPCR in GFP injected and DYRK1A overexpressed embryos at corresponding assay. Embryo orientations: 50% Epiboly stage, top view with the dorsal oriented at the right; 8-somite, dorsal view with anterior oriented at the top; Prim-5 stage, lateral views with anterior oriented toward the left. Arrows show the normal location of PGCs, arrowheads demonstrate the aberrant position of PGCs induced by overexpressed DYRK1A.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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