FIGURE

Fig. 4 S1

ID

ZDB-FIG-180208-15

Publication

Donat et al., 2018 - Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis

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Fig. 4 S1

The region of Notch activity within the endocardium is expanded in krit1^ty219c mutants.

(A, B) Projections of confocal z-stack images of embryonic hearts marked by Tg(TP1:VenusPEST)^s940 expression (yellow), Myh6 staining (cyan), and Actin staining (magenta) at 54 hpf. (A) In wild-type (WT), Notch activity is highest in endocardial cells of the atrioventricular canal (AVC) and outflow regions. (B) In krit1^ty219c mutants, the domain of high Notch activity is expanded to ventricular and atrial endocardial cells. (C, D) Whole-mount in situ hybridization of tbx2 cardiac expression at 48 hpf. (A) Tbx2 expression is restricted to the atrioventricular canal (AVC) both in wild-type (WT) and in ccm2^m201 mutants (B). Arrowheads point at the AVC. A: atrium, V: ventricle, Scale bars are 50 μm (A, B).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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