FIGURE

Fig. 5

ID

ZDB-FIG-180122-35

Publication

Song et al., 2017 - Coral-Derived Natural Marine Compound GB9 Impairs Vascular Development in Zebrafish

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Fig. 5

GB9 exposure reduces the expression of vascular markers. (A–H) Compared to wild-type controls (A,C,E,G), expression of the arterial marker ephrinb2 (B), venous markers mrc1 (D), pan-vascular marker flk1 (F), and stabilin (H) were reduced in the trunk dorsal aorta (a), vein (v), vessels (ve), and caudal vein plexus (cvp) at 24 hpf in GB9 treatment embryos. (I) Quantification of the relative expression level by qPCR assay showed a ~40% and 30% reduced expression in vascular markers ephrinb2 (0.65 ± 0.13), mrc1 (0.58 ± 0.05), flk (0.7 ± 0.14) and stabilin (0.84 ± 0.2) in GB9 treatment embryos. Values on the top right indicate the number of embryos exhibiting phenotype per total number of embryos analyzed. *** refers to p < 0.0001 and ** refers to p < 0.001 by an unpaired Student’s t-test. Data are represented as means ± SD. Scale bars represent 200 μm in (A–H).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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