FIGURE

Fig. 5

ID

ZDB-FIG-171206-5

Publication

Cai et al., 2016 - Neurogenesis-Promoting Natural Product α-Asarone Modulates Morphological Dynamics of Activated Microglia

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Fig. 5

α-asarone affects microglial morphological dynamics in vivo. E. coli was inject into the gap the optic tectum region (A) of the transgenic Tg(Apo-E:eGFP) zebrafish. Time-lapse images were taken at 5-min intervals (B). Zebrafish pre-incubated with α-asarone showed decreased activation, n = 3 (C). The pre-treatment did not cause significant effect to the average migration velocity (E), but the dynamics of velocity change was significant (D). Results were normalized to “0 min” value. α-asarone treatment resulted significant declines in both dynamical changes and average numbers of tips (F,G). α-asarone treatment did not affect the cell area (H,I). (*p < 0.05, unpaired two-tailed Student t-test for independent data comparison vs. E. coli injection; ***p < 0.001, two-way ANOVA for group comparison between the dynamical trends, the numbers were on the bars).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.