ZFIN Image: Cai et al., 2016, Fig. 5

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Figure Caption

Fig. 5

α-asarone affects microglial morphological dynamics in vivo. E. coli was inject into the gap the optic tectum region (A) of the transgenic Tg(Apo-E:eGFP) zebrafish. Time-lapse images were taken at 5-min intervals (B). Zebrafish pre-incubated with α-asarone showed decreased activation, n = 3 (C). The pre-treatment did not cause significant effect to the average migration velocity (E), but the dynamics of velocity change was significant (D). Results were normalized to “0 min” value. α-asarone treatment resulted significant declines in both dynamical changes and average numbers of tips (F,G). α-asarone treatment did not affect the cell area (H,I). (*p < 0.05, unpaired two-tailed Student t-test for independent data comparison vs. E. coli injection; ***p < 0.001, two-way ANOVA for group comparison between the dynamical trends, the numbers were on the bars).

Acknowledgments

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