Fig. S7
- ID
- ZDB-FIG-171201-38
- Publication
- Khatri et al., 2016 - Down-regulation of coasy, the gene associated with NBIA-VI, reduces Bmp signaling, perturbs dorso-ventral patterning and alters neuronal development in zebrafish
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Bmp activity at 30 hpf in the transgenic line Tg(MBmp:EGFP) and rescue by CoA injection Representative images of Tg(Bmp:EGFP) embryos not-injected (A, B) and injected with 1.2 pmol/embryo of ST-MO (C, D) or coasy-MO (E, F) at 30 hpf. A net reduction of the fluorescence intensity is evident in coasy-morphants. Results are from one representative experiment with at least 38 embryos out of two independent replicates. CoA (0.5 pmol/embryo) was injected in the craniofacial area of Tg(Bmp:EGFP) morphants at 24 hpf (I) and Bmp activity compared to that of untreated embryos (G, H) at 60 hpf. One representative experiment out of two replicates. |