FIGURE

Fig. 1

ID

ZDB-FIG-171030-27

Publication

Lou et al., 2015 - Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest

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Fig. 1

Multiple neural crest-derived phenotypes in mutant embryos. a Images of embryo morphology at 72 hpf. b to e Melanocyte defects in mutants at 48 hpf. Dorsal view with anterior to top. Scale bars, 1 mm. j to p and r to t) Alcian blue staining of cartilage reveals defects in neurocranium and viscerocranium formation in mutant embryos at 96 hpf. At least 15 embryos for each genotype were analyzed and representative samples are showed. Compared to single brg1 or med14 mutants, embryos bearing an additional copy of med14 or brg1 null allele show a more severe phenotype. Ventral view with anterior to the top. bh, basihyal; cb, ceratobranchial; ch, ceratohyal; ep, ethmoid plate; hs, hyosymplectic; m, Meckel’s cartilage; pc, parachordal plate; pq, palatoquadrate; tr, trabeculae. q Quantification of melanocyte number at 48 hpf on the trunks of control and mutant embryos. Twelve embryos for each genotype were counted. Error bars represent the SD

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	med14^s231/s231 smarca4a^s481/s481 med14^s231/+; smarca4a^s481/s481 med14^s231/s231; smarca4a^s481/+ med14^s231/s231; smarca4a^s481/s481
Observed In:	basihyal cartilage ceratobranchial 1 cartilage ceratobranchial 2 cartilage ceratobranchial 3 cartilage ceratobranchial 4 cartilage ceratobranchial 5 cartilage ceratohyal cartilage ethmoid cartilage eye hyosymplectic cartilage Meckel's cartilage melanocyte neurocranial trabecula neurocranium palatoquadrate cartilage parachordal cartilage pharyngeal arch 6 pharyngeal arch 7 pigmentation whole organism
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.