FIGURE

Fig. S5

ID

ZDB-FIG-170907-23

Publication

Pfefferli et al., 2017 - The careg element reveals a common regulation of regeneration in the zebrafish myocardium and fin

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Fig. S5

The careg reporter is activated in other injury models of tissue regeneration in zebrafish.

(a-d) In-situ hybridization (purple) on longitudinal fin sections reveals that, as in the amputation model, the endogenous ctgfa gene is not upregulated in the regenerating fin after cryoinjury. (a, c) A probe against a blastema marker, msxb, was used as a positive control to detect the activated mesenchyme. (b, d) A ctgfa probe does not label the regenerating fin tissues. M, mesenchyme; E, epidermis. Brackets indicate the damaged tissue remaining at the tip of the cryoinjured stump. N=3. (e-i) Live-imaging of the larval tail of careg:dmKO2 fish at different days post-fertilization (dpf) and post-amputation. The transgenic reporter is constitutively expressed in the notochord. After amputation (dashed line), the expression of careg:dmKO2 is markedly upregulated at the tip of the regenerating tail. N=6.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.