FIGURE

Fig. 7

ID

ZDB-FIG-170725-12

Publication

Ferre-Fernández et al., 2017 - Whole-Exome Sequencing of Congenital Glaucoma Patients Reveals Hypermorphic Variants in GPATCH3, a New Gene Involved in Ocular and Craniofacial Development

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Fig. 7

Analysis of gpatch3 knock-down-associated phenotypes in zebrafish morphant embryos.

Gpatch3^ATG MO-injected zebrafish embryos were analyzed at 96 hpf, and four phenotypes (Ph-1-4) with increasing severity were described. Lateral and ventral brightfield micrographs show altered phenotypes including microphthalmia (blue arrowheads), mouth and branchial arches (red arrowheads) and pectoral fins (green arrowheads) maldevelopment and pericardial (black arrowheads) and periocular (empty arrowheads) edemas. Scale bars represent 200 ?m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + MO1-gpatch3
Knockdown Reagent:	MO1-gpatch3
Observed In:	brain cranium eye mandibular arch skeleton pectoral fin cartilage pericardium pharyngeal arch 3-7
Stage:	Day 4

Phenotype Detail

Acknowledgments

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