FIGURE

Fig. 1

ID

ZDB-FIG-170607-17

Publication

Benedetti et al., 2016 - INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

Spinal cord and lateral muscle histological analyses.

Each adult fish was transversely cut into five segments (S1–S5) using the fins as anatomical references (see Supp. Figure S2). (A) Hematoxylin & eosin-stained histological sections of the S2 segment of the spinal cord (upper panels; scale bar: 50 μm) and white muscle fibres (lower panels; scale bar: 25 μm) in control (Ctrl), wtSod1 and mSod1 zebrafish. Muscular atrophy and edema (*) with infiltrating cells (arrowhead) are visible in mSod1 lateral muscle. (B) The plots show the significant reduction in spinal cord area and the number of motor neurons throughout the spinal cord, and a significant reduction in the calibre of white muscle fibres along the mSod1 fish trunk. Each point in the plots shows the mean value ± SEM of the indicated parameter in each segment of seven animals for each genotype. The measures were statistically analyzed using two-way ANOVA, and corrected by means of Sidak’s multiple comparison test (*P < 0.05; **P < 0.01; ***P < 0.001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	os4Tg/+ os10Tg/+
Observed In:	motor neuron myotome myotome fast muscle cell spinal cord
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.