FIGURE

Fig. 1

ID

ZDB-FIG-170519-21

Publication

Lei et al., 2017 - Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors

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Fig. 1

The CNS and spinal cord undergo apoptosis and fail to differentiate in fn10a mutants. (A, A) An fn10a mutant (A) showing morphological defects in the brain and tail compared with a wild-type sibling (sib) embryo (A). (B, B’) TUNEL staining showing that the fn10a mutant (B) had severe apoptosis in the CNS and neural tube. (C–F, C’–F’) In situ staining for neural markers revealed that differentiated neuronal markers (D–D’, map2; E–E’, tuba; F–F’, pax2) but not a neural progenitor marker (C–C’, nestin) were affected in fn10a mutants (C–F) compared with those in their siblings (C–F). Scale bars, 200 μm. The number of embryos assayed was ≥13 for each panel.

Expression Data

Genes:	map2 nes pax2a
Fish:	TL eftud2^fn10a/fn10a (TL)
Anatomical Terms:	brain neuroblast (sensu Vertebrata) brain neuron
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	eftud2^fn10a/fn10a (TL)
Observed In:	brain brain neuron caudal fin central nervous system apoptotic process head spinal cord apoptotic process
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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