FIGURE

Fig. S3

ID

ZDB-FIG-170209-21

Publication

Sotolongo-Lopez et al., 2016 - Genetic Dissection of Dual Roles for the Transcription Factor six7 in Photoreceptor Development and Patterning in Zebrafish

Other Figures

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Fig. S3

six7 functions in photoreceptor progenitor cells.

(A) Histological sections of chimera retinas labeled for rods (4C12, green). six7-MO donor cells (red) preferentially generate rods compare to WT donor cells. Note the gap in rod labeling in WT/WT controls. Graph represents the percentage of donor cells that differentiate as rods in the central retina of WT/WT (n = 5) and six7-MO1/WTchimeras (n = 6). *p<0.05, student t test. (B) rx1-, pax6a-, crx- and neurod-in situ hybridization (blue) in a retinal cryosection from 48-hpf WT and six7-MO1 embryos. No labeling of retinal progenitors cell markers (rx1 and pax6a) were observed in the ONL of six7-morphant retinas. (C) Whole-mount in situ hybridization for the dorsal (tbx2b), midline (cyp26c1) and ventral (vax2) retinal marker. Labeling was indistinguishable different between WT and mutant embryos.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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