Fig. 3
- ID
- ZDB-FIG-161122-4
- Publication
- Bhattarai et al., 2016 - IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain
- Other Figures
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Aβ42-Dependent Stem Cell Proliferation Requires Microglial Activity (A–D) L-plastin and HuC/D in control peptide/control liposome (A), control peptide/clodronate liposome (B), TR-Aβ42/control liposome (C), and TR-Aβ42/clodronate liposome (D) injections. Right panels: green channel. (E) S100β and PCNA in brains injected with the four combinations in (A–D). (F) Quantification of the number of L-plastin-positive cells. (F') Quantification of proliferating NSPCs. (G) Examples of ramified and round/ameoboid L-plastin-positive cells. Round cells are around amyloid (green, 4G8 staining). (H) Quantification for the average number of PCNA-positive cells in clodronate-injected brains. Scale bars, 50 μm. Data are represented as mean ± SD; n = 4 fish. ∗p < 0.05; ∗∗∗p < 0.001; n.s., not significant. See also Tables S1 and S2. |