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Fig. 3

ID: ZDB-IMAGE-161122-3
Publication: Bhattarai et al., 2016 - IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-β42 Aggregation in Adult Zebrafish Brain
All Figures: Figures for Bhattarai et al., 2016

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Figure Caption

Fig. 3

Aβ42-Dependent Stem Cell Proliferation Requires Microglial Activity

(A–D) L-plastin and HuC/D in control peptide/control liposome (A), control peptide/clodronate liposome (B), TR-Aβ42/control liposome (C), and TR-Aβ42/clodronate liposome (D) injections. Right panels: green channel.

(E) S100β and PCNA in brains injected with the four combinations in (A–D).

(F) Quantification of the number of L-plastin-positive cells.

(F') Quantification of proliferating NSPCs.

(G) Examples of ramified and round/ameoboid L-plastin-positive cells. Round cells are around amyloid (green, 4G8 staining).

(H) Quantification for the average number of PCNA-positive cells in clodronate-injected brains.

Scale bars, 50 μm. Data are represented as mean ± SD; n = 4 fish. ^∗p < 0.05; ^∗∗∗p < 0.001; n.s., not significant. See also Tables S1 and S2.

Acknowledgments

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