FIGURE

Fig. 8

ID

ZDB-FIG-160819-48

Publication

Dupret et al., 2016 - The Polycomb Group Protein Pcgf1 Is Dispensable in Zebrafish but Involved in Early Growth and Aging

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Fig. 8

Phenotype of 12 month-old pcgf1^-/- mutants.

(A) Pictures of 12 month-old pcgf1^+/+ and pcgf1^-/- fish. Note that both male and female pcgf1^-/- fish exhibit mild spinal curvature. (B) Measurements of the spinal curvature score in 12 month-old fish from the pcgf1^+/+ and pcgf1^-/- populations. Statistical significance was assessed by Student t-test analysis and significance expressed as the value of p. (C) Senescence-associated β-galactosidase (SA-β-Gal) activity in 12 month-old zebrafish. Whole body staining of SA-β-Gal activity in pcgf1^+/+ and pcgf1^-/- fish harboring a spinal curvature are compared. (D) Quantification of SA-β-Gal activity in pcgf1^+/+ and pcgf1^-/- fish. Blue pixels obtained by whole body staining of SA-β-Gal activity were quantified in the trunk area between the operculum and the dorsal and anal fins by Adobe Photoshop and plotted using Prism (GraphPad). Error bars indicate ± SD.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pcgf1^ul1/ul1 (TU)
Observed In:	beta-galactosidase activity cellular senescence spinal cord
Stage:	Adult

Phenotype Detail

Acknowledgments

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