Fig. 4
- ID
- ZDB-FIG-160524-21
- Publication
- Ohnmacht et al., 2016 - Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish
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Motor neuron regeneration is enhanced by application of a dopamine agonist. (A) Experimental time line. (B,C) Double-labelled Hb9:GFP+/EdU+ neurons are indicated by arrowheads. (B′-C′′′) Double-labelled cells from B,C (asterisks) are indicated by arrowheads in single optical sections at higher magnification. (D) Pergolide treatment during the regeneration phase significantly increases the number of Hb9:GFP+/EdU+ double-labelled motor neurons (t-test, **P=0.0092; DMSO, n=12; Pergolide, n=9). Lateral views are shown; rostral is left, dorsal is up. The lesion site is indicated by a dashed line. Values are means ± s.e.m. Scale bars: 50µm in B for B,C; 10µm in B′′′ for B′-C′′′. |