FIGURE

Fig. 6

ID

ZDB-FIG-160523-10

Publication

Abrams et al., 2016 - Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility, and vascular function in zebrafish

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Fig. 6

Zebrafish myh11 mutations alter intestinal transit. (A,B) Intestinal transit as measured by the expulsion of fluorescent microspheres in wild-type and sibling homozygous mlt larvae injected with a myh11 morpholino (MO) (A), and wild-type and sibling S237Y homozygous larvae (B). Anterior: beads remain in anterior intestinal bulb; posterior: beads remain in mid- and posterior intestine; expelled: no beads remaining in the intestine. ****P<0.001. Chi-squared test performed with 2 degrees of freedom. (C) Time lapse of a wild-type (WT) larva beginning when the fluorescent beads are present in the anterior intestine and followed until bead expulsion. A, M, P, location of anterior intestine, mid-intestine and posterior intestine, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	myh11a^m498/m498 + MO1-myh11a myh11a^p318/p318 + MO1-myh11a
Knockdown Reagent:	MO1-myh11a
Observed In:	intestine intestine peristalsis
Stage:	Day 6

Phenotype Detail

Acknowledgments

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