FIGURE

Fig. 2

ID

ZDB-FIG-160505-24

Publication

Tan et al., 2016 - Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma

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Fig. 2

HEXIM1 Activity Suppresses Melanoma In Vivo

(A) 19-week-old Tg(mitfa:BRAF^V600E);p53^-/-;mitfa^-/- zebrafish are shown with rescued melanocytes expressing tumor accelerator SETDB1, background control EGFP, or HEXIM1/hexim1 in the MiniCoopR system.

(B) Tumor-free survival curves for EGFP, SETDB1, and HEXIM1/hexim1 MiniCoopR zebrafish over 25 weeks. Percentages of the total number of zebrafish that were tumor free each week are plotted.

(D) Tumor-free survival curves for MiniCoopR expression of p53 and hexim CRISPRs are shown.

(E) Tumor growth rates of individual mouse xenografts with a Tet-On HEXIM1-inducible A375 cell line (A375-HEXIM1) over 14 days. Mice were fed either a standard diet or doxycycline diet (mean of seven replicates ± SD).

See also Figure S2.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mitfa^w2/w2; tp53^zdf1/zdf1; czt13Tg
Observed In:	melanocyte whole organism melanoma
Stage:	Adult

Phenotype Detail

Acknowledgments

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