FIGURE

Fig. 7

ID

ZDB-FIG-160208-36

Publication

Shen et al., 2015 - Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish

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Fig. 7

Msrb3 morphants are profoundly deaf. (A,C) Examples of C-shaped startle responses of different larval types after sound stimuli (500 Hz; 10 ms). The escape response of control larvae was initiated 5-13 ms after the sound stimulation. Abnormal swimming behavior of msrb3 morphants indicated a defective balance system. Some morphants had no response to voice stimulation. After co-injection with human MSRB3A mRNA (hM3A), In2MO and Ex2MO zebrafish regained some hearing. (B,D) Average C-startle response probability. For each group, 30 larvae were tested. *** P<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-msrb3 AB + MO2-msrb3
Knockdown Reagents:	MO1-msrb3 MO2-msrb3
Observed In:	sensory perception of sound startle response swimming behavior
Stage:	Day 5

Phenotype Detail

Acknowledgments

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