FIGURE

Fig. 4

ID

ZDB-FIG-160208-34

Publication

Shen et al., 2015 - Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish

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Fig. 4

Down-regulation of msrb3. L1-8 neuromasts were decreased and disordered and hair cells were reduced. (A,B; D,E) Hair cells in lateral line neuromasts stained with FM-1-43FX. (A,B) In2MO and Ex2MO morphants had fewer and more disordered primary neuromasts than controls. Scale bars: 150 µm. (D,E) Msrb3 morphants had fewer hair cells per neuromast than controls. Scale bars: 5 µm. (C) Statistical analysis of the L1-8 neuromasts in mismatch controls and msrb3 morphants, “n” represents fish number. (F) Statistical analysis of hair cells per neuromast in mismatch controls and msrb3 morphants, “n” represents neuromasts number. Error bars are s.d. ***P<0.0001.

Expression Data

Gene:	GFP
Fish:	s356tTg s356tTg + MO1-msrb3 s356tTg + MO2-msrb3
Knockdown Reagents:	MO1-msrb3 MO2-msrb3
Anatomical Term:	neuromast hair cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s356tTg + MO1-msrb3 s356tTg + MO2-msrb3
Knockdown Reagents:	MO1-msrb3 MO2-msrb3
Observed In:	neuromast neuromast hair cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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