FIGURE

Fig. S2

ID

ZDB-FIG-151214-56

Publication

Takeuchi et al., 2015 - LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2

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Fig. S2

Nonhematopoietic defects in lsd1^it627 embryos. (A) Expression of lsd1 at the indicated developmental stages was analyzed in WT or lsd1^it627 embryos. Ubiquitous expression of lsd1 in zebrafish embryos was impaired in lsd1^it627 mutants. (B) Survival rates of lsd1^it627 mutants calculated using the Kaplan–Meier method. (C) Results of a comparison of the phenotypes between lsd1^it627 and gata1^m651 mutants at 4 dpf. The arrows and arrowheads indicate the swim bladder and erythrocytes in the heart, respectively. The presence of pale erythrocytes due to erythropoietic defects was detected in both lsd1^it627 and gata1^m651 mutants, whereas defects in the swim bladder were only observed in lsd1^it627 mutants.

Expression Data

Genes:	kdm1a kdrl
Fish:	AB/TL kdm1a^it627/it627 (AB)
Anatomical Term:	whole organism
Stage Range:	2-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	gata1a^m651/m651 kdm1a^it627/it627 (AB)
Observed In:	erythrocyte differentiation swim bladder inflation whole organism
Stage Range:	1-4 somites to Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA