Gene
kdm1a
- ID
- ZDB-GENE-030131-7828
- Name
- lysine (K)-specific demethylase 1a
- Symbol
- kdm1a Nomenclature History
- Previous Names
-
- kdm1
- aof2
- lsd1 (1)
- wu:fb82e06
- wu:fc51a02
- wu:fj36a05
- wu:fj66b06
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have several functions, including chromatin binding activity; flavin adenine dinucleotide binding activity; and histone demethylase activity (H3-dimethyl-K4 specific). Involved in nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to localize to nuclear chromatin. Is expressed in brain; head; intestine; and spinal cord. Orthologous to human KDM1A (lysine demethylase 1A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myelodysplastic syndrome | AB + MO4-kdm1a | standard conditions | Wu et al., 2021 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002937 | Amine oxidase |
| Domain | IPR007526 | SWIRM domain |
| Family | IPR017366 | Lysine-specific histone demethylase |
| Family | IPR050281 | Flavin monoamine oxidase and related enzymes |
| Homologous_superfamily | IPR009057 | Homedomain-like superfamily |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Amine oxidase | FAD/NAD(P)-binding domain superfamily | Flavin monoamine oxidase and related enzymes | Homedomain-like superfamily | Lysine-specific histone demethylase | SWIRM domain | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F6NIA2
|
833 | |||||||
|
UniProtKB:A0A0P0UQI8
|
830 | |||||||
|
UniProtKB:A0JMQ3
|
848 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kdm1a-201
(1)
|
Ensembl | 3,367 nt | ||
| mRNA |
kdm1a-202
(1)
|
Ensembl | 887 nt | ||
| mRNA |
kdm1a-203
(1)
|
Ensembl | 500 nt | ||
| mRNA |
kdm1a-204
(1)
|
Ensembl | 456 nt | ||
| mRNA |
kdm1a-207
(1)
|
Ensembl | 606 nt | ||
| mRNA |
kdm1a-208
(1)
|
Ensembl | 5,311 nt | ||
| ncRNA |
kdm1a-005
(1)
|
Ensembl | 975 nt | ||
| ncRNA |
kdm1a-006
(1)
|
Ensembl | 1,015 nt |
Interactions and Pathways
No data available
Plasmids
No data available