ZFIN ID: ZDB-GENE-030131-7828
Gene Name: lysine (K)-specific demethylase 1a
Gene Symbol: kdm1a    Nomenclature History

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Previous Names: kdm1, aof2, lsd1 (1), wu:fb82e06, wu:fc51a02, wu:fj36a05, wu:fj66b06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have several functions, including chromatin binding activity; flavin adenine dinucleotide binding activity; and histone demethylase activity (H3-dimethyl-K4 specific). Involved in nervous system development; regulation of hemopoiesis; and regulation of retinoic acid biosynthetic process. Predicted to localize to nuclear chromatin. Is expressed in brain; head; intestine; and spinal cord. Orthologous to human KDM1A (lysine demethylase 1A).
Genome Resources: Alliance (1),  Gene:558450 (1),  Ensembl(GRCz11):ENSDARG00000060679 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
aik5 Small Deletion Exon 1 Missense, Premature Stop CRISPR
it627 Point Mutation Exon 17 Premature Stop ENU
sa23095 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28869 Point Mutation Unknown Unknown ENU
    sa36433 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42949 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdm1a 1
    MO1-kdm1a N/A 1
    MO2-kdm1a N/A 3
    MO3-kdm1a N/A 1
    MO4-kdm1a N/A 1
    MO5-kdm1a N/A 1
    DISEASE ASSOCIATED WITH kdm1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cleft palate, psychomotor retardation, and distinctive facial features 616728
    DISEASE ASSOCIATED WITH kdm1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of retinoic acid biosynthetic process (more)
    Cellular Component nucleus (more)
    Molecular Function flavin adenine dinucleotide binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm1a-201 (1)    Ensembl 3367
    kdm1a-202 (1)    Ensembl 887
    kdm1a-203 (1)    Ensembl 500
    kdm1a-204 (1)    Ensembl 456
    kdm1a-207 (1)    Ensembl 606
    ncRNA kdm1a-005 (1)    Ensembl 975
    kdm1a-006 (1)    Ensembl 1015
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm1a No data available
    MARKER RELATIONSHIPS
    kdm1a Contained in: [BAC] DKEY-265G24 (1) (order this)
    kdm1a Encodes: [EST] fb82e06, fc51a02, fj36a05, fj66b06
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001242995 (1)
    Genomic GenBank:AL844186 (1) 221158 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q8P2 (1) 858 aa
    Sequence Information (all 29)
    ORTHOLOGY for kdm1a ( Chr: 17 )
    CITATIONS (30)