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ZFIN ID: ZDB-FIG-151210-21
Rissone et al., 2015 - Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress. The Journal of experimental medicine   212(8):1185-202 Full text @ J. Exp. Med.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage Range: Prim-5 to Day 5
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-15 to Day 5

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
cdh5 ak2hg14/hg14 control Prim-5 vasculature endothelial cell ISH
Prim-15 vasculature endothelial cell ISH
Prim-25 vasculature endothelial cell ISH
DsRed ak2hg14/hg14; sd2Tg; y1Tg control Prim-5 nucleate erythrocyte IFL
Prim-15 nucleate erythrocyte IFL
Long-pec nucleate erythrocyte IFL
sd2Tg; y1Tg control Long-pec nucleate erythrocyte IFL
EGFP ak2hg14/hg14; sd2Tg; y1Tg control Prim-5 trunk vasculature IFL
Prim-15 trunk vasculature IFL
Long-pec trunk vasculature IFL
la2Tg control Day 4 hematopoietic multipotent progenitor cell IFL
Day 4 thrombocyte IFL
la2Tg + MO1-ak2 control Day 4 hematopoietic multipotent progenitor cell IFL
Day 4 thrombocyte IFL
la2Tg + MO1-ak2 + MO2-ak2 control Day 4 hematopoietic multipotent progenitor cell IFL
Day 4 thrombocyte IFL
la2Tg + MO2-ak2 control Day 4 hematopoietic multipotent progenitor cell IFL
Day 4 thrombocyte IFL
sd2Tg; y1Tg control Long-pec trunk vasculature IFL
myb EKW control Prim-15 hematopoietic multipotent progenitor cell ISH
Prim-15 hematopoietic stem cell ISH
Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
EKW + MO1-ak2 control Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
EKW + MO1-ak2 + MO2-ak2 control Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
EKW + MO2-ak2 control Prim-15 hematopoietic multipotent progenitor cell ISH
Prim-15 hematopoietic stem cell ISH
Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
WT control Prim-15 hematopoietic multipotent progenitor cell ISH
Prim-15 hematopoietic stem cell ISH
Long-pec hematopoietic multipotent progenitor cell ISH
Long-pec hematopoietic stem cell ISH
Protruding-mouth hematopoietic multipotent progenitor cell ISH
Protruding-mouth hematopoietic stem cell ISH
Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
ak2hg14/hg14 control Prim-15 hematopoietic multipotent progenitor cell ISH
Prim-15 hematopoietic stem cell ISH
Long-pec hematopoietic multipotent progenitor cell ISH
Long-pec hematopoietic stem cell ISH
Protruding-mouth hematopoietic multipotent progenitor cell ISH
Protruding-mouth hematopoietic stem cell ISH
Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
ak2hg16/hg16 control Protruding-mouth hematopoietic multipotent progenitor cell ISH
Protruding-mouth hematopoietic stem cell ISH
Day 5 hematopoietic multipotent progenitor cell ISH
Day 5 hematopoietic stem cell ISH
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
EKW + MO1-ak2 control Day 5 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 5 hematopoietic stem cell differentiation decreased process quality, abnormal
EKW + MO1-ak2 + MO2-ak2 control Day 5 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 5 hematopoietic stem cell differentiation decreased process quality, abnormal
EKW + MO2-ak2 control Prim-15 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Prim-15 hematopoietic stem cell differentiation decreased process quality, abnormal
Day 5 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 5 hematopoietic stem cell differentiation decreased process quality, abnormal
ak2hg14/hg14 control Long-pec hematopoietic progenitor cell differentiation decreased process quality, abnormal
Long-pec hematopoietic stem cell differentiation decreased process quality, abnormal
Protruding-mouth hematopoietic progenitor cell differentiation decreased process quality, abnormal
Protruding-mouth hematopoietic stem cell differentiation decreased process quality, abnormal
Day 5 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 5 hematopoietic stem cell differentiation decreased process quality, abnormal
ak2hg16/hg16 control Protruding-mouth hematopoietic progenitor cell differentiation decreased process quality, abnormal
Protruding-mouth hematopoietic stem cell differentiation decreased process quality, abnormal
Day 5 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 5 hematopoietic stem cell differentiation decreased process quality, abnormal
la2Tg + MO1-ak2 control Day 4 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 4 hematopoietic stem cell differentiation decreased process quality, abnormal
la2Tg + MO1-ak2 + MO2-ak2 control Day 4 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 4 hematopoietic stem cell differentiation decreased process quality, abnormal
la2Tg + MO2-ak2 control Day 4 hematopoietic progenitor cell differentiation decreased process quality, abnormal
Day 4 hematopoietic stem cell differentiation decreased process quality, abnormal
Full text @ J. Exp. Med.