FIGURE

Fig. 4

ID

ZDB-FIG-151207-4

Publication

Karra et al., 2015 - Myocardial NF-κB activation is essential for zebrafish heart regeneration

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Fig. 4

NF-κB has pleiotropic inhibitory effects on heart regeneration. (A–C) Section images of cmlc2:CreER; βact2:BS-gata4, cmlc2:CreER; βact2:RS-IκBSR, and cmlc2:CreER; βact2:BS-gata4; βact2:RS-IκBSR ventricles at 30 dpa after treatment with 4-HT. Images are stained for Tnnt to demarcate cardiac muscle. Dashed line indicates approximate resection plane. (D and E) Tilescan images of cmlc2:CreER; βact2:RS-IκBSR; tcf21:nuceGFP ventricles at 14 dpa after treatment with vehicle or 4-HT. Images are stained for Tnnt to denote cardiac muscle. (F) Quantification of tcf21⁺ cell responses in cmlc2:CreER; βact2:RS-IκBSR hearts treated with vehicle (n = 10) or 4-HT (n = 12) at 14 dpa. Error bars indicate SE. *P < 0.05, Student’s t test, two-tailed. (Scale bars: 100 µm.)

Expression Data

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Antibody Labeling

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA