FIGURE

Fig. 4

ID

ZDB-FIG-151125-21

Publication

Okuda et al., 2015 - A zebrafish model of inflammatory lymphangiogenesis

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Fig. 4

The Vegfr pathway is required for zebrafish intestinal inflammatory lymphangiogenesis. (A-C) Lateral images of intestine in 7dpf lyve1:DsRed2 larvae exposed to TNBS+1% DMSO (A), TNBS+2.5nM tivozanib (B) and TNBS+150nM sunitinib (C). Asterisks indicate intestinal lymphatic sprouts (ILSs). (D,E) Quantification of ILS number (D) and total ILS length (E) in TNBS+1% DMSO treated larvae compared with 2.5nM tivozanib, TNBS+2.5nM tivozanib, 150nM sunitinib and TNBS+150nM sunitinib treated larvae (n≥20). Error bars, ±s.d. **P<0.01, ***P<0.001 by one-way ANOVA with Dunnett′s multiple comparison test. L-IL, left intestinal lymphatics; TD, thoracic duct. Scale bar: 100µm.

Expression Data

Gene:	DsRed
Fish:	nz117Tg
Conditions:	chemical treatment: sunitinib chemical treatment: 2,4,6-trinitrobenzenesulfonic acid chemical treatment: 2,4,6-trinitrobenzenesulfonic acid
Anatomical Terms:	intestinal lymphatic network intestinal lymphatic network lymphangiogenic sprout thoracic duct vein
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nz117Tg
Conditions:	chemical treatment: sunitinib chemical treatment: 2,4,6-trinitrobenzenesulfonic acid chemical treatment: 2,4,6-trinitrobenzenesulfonic acid
Observed In:	intestinal lymphatic network lymphangiogenesis intestinal lymphatic network lymphangiogenic sprout
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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