ZFIN ID: ZDB-FIG-151106-24
Liu et al., 2015 - Solute Carrier Family 26 Member a2 (slc26a2) Regulates Otic Development and Hair Cell Survival in Zebrafish. PLoS One   10:e0136832 Full text @ PLoS One
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagent:
Observed In:
Stage: Day 5

Fig. 5

Knockdown of slc26a2 induces semicircular canal defects in larval zebrafish.

(A) Changes in semicircular canal morphology and cilia size (scale bars = 30 µm). (B) Changes of neuromasts numbers and hair cell numbers in lateral line (scale bars = 20 µm). (C, D) Changes of cilia numbers in the inner ear (scale bars = 20 µm). (D) Statistical analysis of the ciliary bundles in the inner ear in different types of embryos at 120hpf, including wild type(WT), mismatch-MO control, S2-SP1 MO and Rescue. (E) Statistical analysis of the L1-8 neuromasts numbers in the posterior lateral line in different types of embryos at 120hpf, including WT, Mis-con, S2-SP1 and Rescue. (F) Statistical analysis of the hair cells numbers per neuromast in different types of embryos at 120hpf, including WT, Miscon, S2-SP1 and Rescue. ***P<0.001.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
AB + MO1-slc26a2 standard conditions Day 5 auditory receptor cell stereocilium decreased amount, abnormal
Day 5 semicircular canal malformed, abnormal
Day 5 somite morphology, normal
s356tTg + MO1-slc26a2 standard conditions Day 5 lateral line neuromast decreased amount, abnormal
Day 5 lateral line neuromast hair cell decreased amount, abnormal
Day 5 neuromast hair cell disorganized, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One