FIGURE

Fig. 6

ID

ZDB-FIG-150928-12

Publication

Zhang et al., 2015 - Remodeling of Mitochondrial Flashes in Muscular Development and Dystrophy in Zebrafish

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Fig. 6

NAD(P)H signal is relatively stable during normal development but reduced in dystrophin morphants.

(A) NAD(P)H signal of white skeletal muscle cells of zebrafish embryo at 5dpf. Scale bar,10µm. (B) Intensity-based segmentation of mitochondria. NAD(P)H signal was defined as mean intensity of mitochondrial regions. (C) NAD(P)H autofluorescence in the mitochondria of red (right) and white (left) skeletal muscle cells of wild-type embryos at 2, 5 and 8 dpf. No significant change of NAD(P)H was observed during development in either red or white fibers. N = 5–13 animals per group. (D) NAD(P)H signal was significantly decreased in both red and white fibers of dys-MO morphants (dys-MO) compared with wild-type (WT) controls. Data are expressed as the mean±SEM. *: p<0.05; **: p<0.01 versus wild-type group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO2-dmd
Knockdown Reagent:	MO2-dmd
Observed In:	fast muscle cell respiratory chain complex slow muscle cell mitochondrion slow muscle cell respiratory chain complex
Stage:	Day 5

Phenotype Detail

Acknowledgments

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