FIGURE

Fig. 1

ID

ZDB-FIG-150512-1

Publication

Burgoyne et al., 2015 - Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

Other Figures

All Figure Page

Back to All Figure Page

Fig. 1

OA1 MOs reduce melanosome number at 2dpf without affecting melanosome size. (A–D) Contrast-enhanced images of zebrafish eye cross-sections highlighting only electron-dense melanin. Images are shown from (A,B) control and (C,D) OA1 MO-treated zebrafish. KD, knockdown. Scale bars: 20µm. (E) At 2dpf there is a significant reduction in melanin area between controls and OA1 MO-treated zebrafish. By 5dpf, the OA1 MO appears to be less effective, resulting in no significant difference in melanin area between controls and OA1 MO-treated animals. (F) The OA1 MO had no apparent effect on melanosome diameter at 2 and 5dpf. Results show the mean±s.e.m.; *P<0.05 (Student′s t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-gpr143
Knockdown Reagent:	MO1-gpr143
Observed In:	retinal pigmented epithelium retinal pigmented epithelium melanosome
Stage Range:	Long-pec to Day 5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.