FIGURE

Fig. 7

ID

ZDB-FIG-150420-39

Publication

Deml et al., 2015 - Mutations in MAB21L2 Result in Ocular Coloboma, Microcornea and Cataracts

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Fig. 7

Analysis of pax6b, pax2.1 and foxe3 expression in wild-type, mab21l2^Q48Sfs*5 and mab21l2^R51_F52del embryos.

Wild-type (A-E) and mutant (F-O) zebrafish embryos at 24–48-hpf were analyzed as indicated in the right bottom corner of each image. Please note a change in pax6b transcript distribution at 24-hpf and 48-hpf in mab21l2^Q48Sfs*5 (arrowheads in F-H), retinal folding defect in mab21l2^R51_F52del embryos at 24-hpf (arrowheads in K, L) and visibly abnormal pax6b pattern at 48-hpf in some (arrowheads in M) but not all (N) mab21l2^R51_F52del embryos. pax2.1 expression seems to be unaffected in 24-hpf frameshift mutant embryos (I) but shows an abnormal pattern in both mutants at 48-hpf (J,O). At 48-hpf, in addition to more broad and intense pax2.1 expression in the region of optic fissure, abnormal pax2.1 staining was detected in central retina in mab21l2^Q48Sfs*5 embryos (arrowheads in J). le, lens; of, optic fissure; retina.

Expression Data

Genes:	pax2a pax6b
Fish:	WT mab21l2^mw701/mw701 mab21l2^mw702/mw702
Anatomical Terms:	cranial nerve II eye lens optic cup optic cup peripheral region optic fissure optic furrow retina retinal ganglion cell retinal inner nuclear layer solid lens vesicle
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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