FIGURE
Fig. 4
- ID
- ZDB-FIG-150409-22
- Publication
- Keßler et al., 2015 - Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish
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Fig. 4
Blockade of the citric acid cycle phenocopies the ste−/− mutant phenotype. a–c, g Morpholino-modified antisense oligonucleotide mediated knockdown of OGDH subunit E1 (MO-E1) (a) or DLDH subunit E3 (MO-E3) (b) of the citric acid cycle phenocopies the ste−/− bradycardia (g), whereas injection of a control Morpholino has no effect (c, g). d–g Incubation of wild-type embryos with the citric acid cycle blocker sodiumfluoroacetate (SFA) and the respiratory chain uncoupler 2,4-dinitrophenol (DNP) phenocopies the heart rate defect of ste−/− mutant embryos in a dose-dependent manner |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
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| Conditions: | |
| Knockdown Reagents: | |
| Observed In: | |
| Stage: | Protruding-mouth |
Phenotype Detail
Acknowledgments
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Full text @ Basic Res. Cardiol.