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Fig. 4
Blockade of the citric acid cycle phenocopies the ste−/− mutant phenotype. a–c, g Morpholino-modified antisense oligonucleotide mediated knockdown of OGDH subunit E1 (MO-E1) (a) or DLDH subunit E3 (MO-E3) (b) of the citric acid cycle phenocopies the ste−/− bradycardia (g), whereas injection of a control Morpholino has no effect (c, g). d–g Incubation of wild-type embryos with the citric acid cycle blocker sodiumfluoroacetate (SFA) and the respiratory chain uncoupler 2,4-dinitrophenol (DNP) phenocopies the heart rate defect of ste−/− mutant embryos in a dose-dependent manner
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Full text @ Basic Res. Cardiol.