FIGURE

Fig. 1

ID

ZDB-FIG-150408-48

Publication

Keßler et al., 2015 - Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish

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Fig. 1

Effects of the ste mutation on cardiac function. a, b Lateral view of wild-type (wt) (a) and ste^−/− mutant (b) embryos at 72 h post-fertilization (hpf). ste^−/− mutants (b) develop blood congestion at the cardiac inflow tract and a pericardial edema. c Heart rate at different time points in ste^−/− mutants (red) and wild-type littermates (blue). Bradycardia in ste^−/− mutants starts at 48 hpf and becomes more severe during further embryonic development. d Ventricular fractional shortening is unaffected in ste^−/− mutants compared to wild-type littermates at 72 hpf (53 ± 2.2 vs. 55 ± 3.1 %, n = 5, p = 0.7096), 96 hpf (58 ± 3.2 vs. 57 ± 1.9 %, n = 5, p = 0.7956) and 120 hpf (59 ± 1.9 vs. 61 ± 1.8 %, n = 5, p = 0.5586)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dlst^{t21498/t21498}
Observed In:	blood heart contraction pericardium sinus venosus
Stage Range:	Protruding-mouth to Day 5

Phenotype Detail

Acknowledgments

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