FIGURE

Fig. 1

ID

ZDB-FIG-150407-1

Publication

Renz et al., 2015 - Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins

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Fig. 1

Loss of CCM Proteins Causes Elevated Levels of klf2 Expression

(A–C) Loss of Ccm2 causes elevated levels of klf2a and klf2b mRNA in zebrafish at 48 hrpf (A), of Klf2 mRNA in mouse cerebellar tissue of iCCM2 mice at P15 (B), and of KLF2 mRNA in HUVECs (C), as determined by qRT-PCR.

(D–H) At 48 hrpf, whole-mount in situ hybridizations show that klf2a is misexpressed within the entire endocardium of krit1^ty219c and ccm2^m201 mutants (D–F) and is elevated within arteries and veins in the tail region (asterisk) of ccm2^m201 mutants (H) compared to WT embryos (G). Statistical data are means and SEM; p < 0.05; p < 0.01; p < 0.001; p < 0.0001; see Supplemental Experimental Procedures for details about statistical data analysis.

Expression Data

Gene:	klf2a
Fish:	WT ccm2^m201/m201 krit1^{ty219c/ty219c}
Anatomical Terms:	caudal fin artery caudal fin vein endocardium
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Cell, 32, Renz, M., Otten, C., Faurobert, E., Rudolph, F., Zhu, Y., Boulday, G., Duchene, J., Mickoleit, M., Dietrich, A.C., Ramspacher, C., Steed, E., Manet-Dupé, S., Benz, A., Hassel, D., Vermot, J., Huisken, J., Tournier-Lasserve, E., Felbor, U., Sure, U., Albiges-Rizo, C., Abdelilah-Seyfried, S., Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins, 181-190, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell