FIGURE

Fig. 3

ID

ZDB-FIG-141024-3

Publication

Zdebik et al., 2013 - Epilepsy in kcnj10 Morphant Zebrafish Assessed with a Novel Method for Long-Term EEG Recordings

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Fig. 3

Analysis of surface EEGs.

(A-C) Original traces (top) and averaged frequency spectra (below) obtained in WT ZF, kcnj10a morphant ZF and WT ZF pretreated with pentylenetetrazol. (D) The averaged amplitudes (mean over 2-4 Hz) from (A-C) are compared. Note the significant epileptic activity in kcnj10a morphant (MO) and pentylenetetrazol-treated (PTZ) ZF. (E-G) Original traces (top) and averaged frequency spectra (below) obtained in kcnj10a morphant fish, and kcnj10a morphants treated with pentobarbitone (PB) or diazepam (DZP), respectively. (H) Averaged amplitudes (mean over 2-4 Hz) from (E-G) are compared. Note the significant suppression of epileptic activity by PB treatment, and lack of suppression by DZP.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO1-kcnj10a
Condition:	chemical treatment: pentobarbital
Knockdown Reagent:	MO1-kcnj10a
Observed In:	whole organism
Stage:	Day 5

Phenotype Detail

Acknowledgments

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