FIGURE

Fig. S2

ID

ZDB-FIG-140811-34

Publication

Ju et al., 2014 - Activation of Sonic hedgehog signaling in neural progenitor cells promotes glioma development in the zebrafish optic pathway

Other Figures

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Fig. S2

The early and late phenotypes of the Tg(krt5:Gal4VP16;14×UAS:smoa1-EGFP) stable transgenic fish. (a) Double transgenic embryo at 30 hpf derived from crossing Tg(krt5:Gal4VP16;14×UAS:smoa1-EGFP) and Tg(UAS-E1b:nfsB-mCherry)^c264 lines. Note the GFP expression in the head region (arrow). (b) The same embryo showing mCherry expression not only in the head region, but also in the skin epithelia (arrow). (c) Dorsal view of a 96 hpf wild-type embryo. (c′) Transverse cryosection of the same embryo showing proper closure of the choroid fissure. (d) Transgenic embryo at 96 hpf showing a coloboma phenotype (arrow), transverse sectioning showing the choroid fissures failed to close (d′, arrow). (e) A two-week-old double transgenic juvenile showing ectopic cell proliferation at the ciliary marginal zones (arrows). (f) A 45-day old zebrafish showing failure to close the choroid fissure (arrow), a feature characteristic of coloboma.

Expression Data

Genes:	EGFP mCherry
Fish:	c264Tg; sj4Tg
Anatomical Terms:	brain integument
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	c264Tg; sj4Tg
Observed In:	optic furrow retina cell population proliferation
Stage Range:	Day 4 to Days 45-89

Phenotype Detail

Acknowledgments

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