ZFIN ID: ZDB-FIG-140714-45
Stawicki et al., 2014 - The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function. Disease models & mechanisms   7:847-856 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Condition:
Anatomical Term:
Stage: Day 5

Fig. 3

Uptake of FM1-43 and hair cell toxicants are reduced in merovingian mutants. (A) There is reduced uptake of FM1-43 into the hair cells of merovingian mutants. Hair cells are expressing the brn3c:gfp transgene. (B) Neomycin-TR fails to enter hair cells of merovingian mutants. (C) Rho-Pt uptake is reduced in merovingian mutants. (D) Quantification of FM1-43, neomycin-TR, and Rho-Pt uptake into hair cells, normalized to background fluorescence (n=10 fish); **P=0.0046, ***P<0.0001 for neomycin-TR and P=0.0006 for Rho-Pt by Student’s t-test, Welch’s correction was used for neomycin-TR and Rho-Pt. Error bars indicate s.d. Scale bars: 10 μm.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP gcm2w40/w40; s356tTg standard conditions Day 5 neuromast hair cell IFL
gcm2w40/w40; s356tTg chemical treatment: pharmaceutical Day 5 neuromast hair cell IFL
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.