ZFIN ID: ZDB-FIG-140714-45
Stawicki et al., 2014 - The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function. Disease models & mechanisms   7:847-856 Full text @ Dis. Model. Mech.
Anatomical Term:
Stage: Day 5

Fig. 3

Uptake of FM1-43 and hair cell toxicants are reduced in merovingian mutants. (A) There is reduced uptake of FM1-43 into the hair cells of merovingian mutants. Hair cells are expressing the brn3c:gfp transgene. (B) Neomycin-TR fails to enter hair cells of merovingian mutants. (C) Rho-Pt uptake is reduced in merovingian mutants. (D) Quantification of FM1-43, neomycin-TR, and Rho-Pt uptake into hair cells, normalized to background fluorescence (n=10 fish); **P=0.0046, ***P<0.0001 for neomycin-TR and P=0.0006 for Rho-Pt by Student’s t-test, Welch’s correction was used for neomycin-TR and Rho-Pt. Error bars indicate s.d. Scale bars: 10 μm.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP gcm2w40/w40; s356tTg standard conditions Day 5 neuromast hair cell IFL
gcm2w40/w40; s356tTg chemical treatment: pharmaceutical Day 5 neuromast hair cell IFL
Antibody Labeling Details No data available
Phenotype Details No data available
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