ZFIN ID: ZDB-FIG-140714-43
Stawicki et al., 2014 - The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function. Disease models & mechanisms   7:847-856 Full text @ Dis. Model. Mech.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Fish:
Anatomical Term:
Stage: Day 5
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 1

merovingian mutants have inner ear defects. (A) merovingian (mero) mutants show multiple phenotypes including a failure to inflate their swim bladders, an enlarged yolk, and impaired otolith formation. Arrowhead points to otolith. (B) Quantification of the size of the posterior otolith in wild-type siblings and merovingian mutants. Otolith size is significantly reduced in merovingian mutants. Mutants were selected randomly and included eight fish lacking a posterior otolith and therefore having an otolith size of 0 (n=10 fish). (C) Hair cells expressing the brn3c:gfp transgene in the lateral crista of both wild-type siblings and merovingian mutants. (D) Quantification of the number of hair cells/crista in wild-type siblings and merovingian mutants. All three crista were used for counting. There is a significant reduction in hair cell number in merovingian mutants (n=9 fish). ***P<0.0001 by Student’s t-test; error bars indicate s.d. Scale bars: 250 μm (A), 10 μm (C).

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
GFP gcm2w40/w40; s356tTg standard conditions Day 5 hair cell IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
gcm2w40/w40 (AB) standard conditions Day 5 hair cell decreased amount, abnormal
Day 5 otolith decreased size, abnormal
Day 5 swim bladder inflation disrupted, abnormal
Day 5 yolk increased size, abnormal
Acknowledgments:
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