FIGURE

Fig. S2

ID

ZDB-FIG-140522-78

Publication

Bonetti et al., 2014 - Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

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Fig. S2

Heart looping defects in embryos expressing Shp2-T73I (NS) and Shp2- G465A (LS). Non-injected control embryos (NIC) and embryos injected at the one-cell stage with mRNA encoding WT-Shp2, Shp2-T73I (NS) or Shp2-G465A (LS) were fixed at 48 hpf and in situ hybridization was performed using probes for the myosin genes myl7 (A-D, cardiomyocytes), vmhc (E-H, ventricle), amhc (I-L, atrium), and for has2 (M-P, endocardial cushions). Representative pictures are shown and the number of embryos showing this pattern as well as the total number of embryos that were analyzed is indicated in the bottom right corner of each panel. The outline of the heart is indicated with a dashed line in panels M-P.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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