FIGURE

Fig. 3

ID

ZDB-FIG-140522-73

Publication

Bonetti et al., 2014 - Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish

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Fig. 3

Randomized heart displacement in response to expression of Shp2-D61G and Shp2-A462T. Embryos were injected at the one-cell stage with mRNA encoding WT-Shp2, Shp2-D61G or Shp2-A462T and fixed at the 16-somite stage, the 22-somite stage or at 28hpf. In situ hybridization was carried out using a myl7-specific probe to mark cardiomyocytes. (A-H) The number of embryos displaying the depicted pattern/total number of embryos is indicated. (I-K) Representative pictures are shown displaying heart displacement to the left (I), middle (J) and right (K). (L) Percentages of left, middle and right cardiac displacement are depicted. The number of embryos (n) is indicated.

Expression Data

Gene:	myl7
Fish:	WT
Anatomical Term:	cardiac muscle cell
Stage Range:	14-19 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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